Archive for July 2011
In animal studies mice, rats and dogs were involved. They were treated with tadalafil to estimate the toxicology of the drug.
Animal studies demonstrated vascular inflammation in animals. In mice and rats lymphoid necrosis and hemorrhage were seen in the spleen. In dogs the increased risk of disseminated arthritis was seen in 6 month studies. In a 12- month dog study, two dogs got marked decreases in white blood cells (neutrophils) and moderate decreases in platelets with inflammatory signs. Still these abnormalities disappeared after 2 weeks of removal of the drug.
Reproductions studies have shown no evidence of impaired fertility in mice and rats treated with tadalafil.
Teratogenicity, embryotoxicity and fetotoxicity have demonstrated no signs also: tadalafil was given to pregnant rats and mice.
Tadalafil and its metabolites were observed to cross the placenta, resulting in fetal exposure in rats. Tadalafil and its metabolites were found in the milk of lactating rats in higher concentrations than in plasma.
If you experience any unusual or strange side effects of Cialis, stop using it and call your doctor immediately. Uncommon side effects are rare reported adverse reactions which patients have after Cialis has been administered.
Uncommon side effects are:
Color vision changes are very rare and may include difficulty in telling the difference between blue and green colors, seeing blue shade to objects and other color vision altering.
Priapism is a prolonged and painful erection, which happen in very small number of people, but is a very dangerous condition. If this serious condition is not treated properly and in time, it can lead to complete penis damage. So this condition should be treated as soon as possible. If you experience unusual prolonged erection, do not wait, call your doctor.
In rare cases, men taking PDE5 inhibitors, including tadalafil, reported a sudden loss of vision in one or both eyes. If you have such a condition, get emergency medical help right away. Still it is not proved if Cialis taking is associated with this vision loss.
A very small group of people taking Cialis reported unusual side effects which can be characterized like decrease of hearing. Some of them experienced ringing in the ears and dizziness. This side effect is also can be directly related to the usage of Cialis. If you have sudden decrease of hearing or hearing loss, call your doctor right away.