Normal erection is a reflex caused by increased penile blood flow during sexual stimulation. The sexual response is a result of relaxation of penile arteries and corpus cavernosal smooth muscles due to the release of nitric oxide (NO). the inhibition of phosphodiesterase type 5 (PDE 5) makes erectile function better by enlarging the cGMP (cyclic Guanosine Monophosphate) which relaxes smoothe muscles tissues. In blood vessels relaxation of vascular smooth muscles lead to vasodilation and increased blood flow. The main component of Cialis tadalafil inhibits PDE 5 and improves erectile function by increasing the cGMP. Still the effect will be min if there is no sexual stimulation. Sexual stimulation is necessary to release nitric oxide.

Clinical studies have confirmed that a selective inhibitor of PDE5 is found in corpus cavernosum smooth muscle, vascular and visceral smooth muscle, kidney, lung, and pancreas. The same studies proved that the effect of tadalafil is more potent on PDE5 than on other phosphodiesterases.

Cialis relaxes muscles and increases blood flow to particular areas of the body. The effect of the drug appears in 30 minutes after taking and lasts for about 36 hours. A male taking  Cialis for the first time should consider the dose prescribed very carefully. An overdose of Cialis is possible if a person does not follow the prescribed dose and takes much of this drug.

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